Are you looking for a medically guided, non-surgical approach to weight loss? If so, you are not alone. Today, many people want real results without surgery. As a result, interest in advanced peptide therapies continues to rise.
At the same time, patients want options that are safe and supervised. For that reason, physician-guided care matters. At Azani Medical Spa in Bethlehem, PA, we focus on structured, evidence-informed peptide therapy.
One option now gaining attention is Retatrutide. So, in this guide, we explain what Retatrutide is. Next, we review current clinical research. Then, we compare it with Wegovy and Zepbound. Finally, we explain how to begin peptide therapy safely.
What Is Retatrutide?
Retatrutide is an investigational triple-agonist peptide. In simple terms, it acts on three key metabolic receptors:
• GLP-1
• GIP
• Glucagon
Together, these receptors influence appetite, insulin response, and energy use. Because of this, Retatrutide does more than reduce hunger alone.
Instead, it works across several metabolic pathways. As a result, researchers believe it may help people feel full sooner. In addition, it may reduce calorie intake. Over time, it may also improve metabolic efficiency.
If you want more detail, our science-focused article explains these pathways clearly:
👉 How Retatrutide Works for Weight Loss
Latest Clinical Trial Results
So far, Retatrutide has shown some of the strongest results in medical weight loss research.
In Phase 2 and emerging Phase 3 trials:
• Participants achieved ~24% weight loss at 48 weeks
• Later data suggests ~28–29% average weight loss at ~68 weeks
• Additionally, many participants showed improved insulin sensitivity
Because of these findings, Retatrutide is now considered one of the most advanced peptides under study.
However, it is important to be clear. Retatrutide is still investigational. At this time, it is not FDA-approved. Therefore, it is discussed only within medically supervised peptide programs.
Retatrutide vs Wegovy vs Zepbound
Naturally, patients want comparisons. So, let’s look at how these options differ.
First, Semaglutide (Wegovy) is a GLP-1 therapy. Currently, it is widely prescribed for weight loss. In trials, average weight loss is around 15%. For many people, this works well. Although, plateaus can occur.
Next, Tirzepatide (Zepbound) introduced a dual-pathway approach. Specifically, it targets GLP-1 and GIP receptors. As a result, studies show average weight loss of about 20–21%. Because of this, it outperformed earlier GLP-1 therapies.
Now, Retatrutide goes one step further. In addition to GLP-1 and GIP, it activates the glucagon receptor. Because of this, it may increase energy use and fat burning, not just appetite control.
Clinical Comparison Table
| Medication | Receptor Targets | Typical Trial Weight Loss | FDA Status |
| Retatrutide | GLP-1 + GIP + Glucagon | ~24–29% (investigational) | Clinical trials |
| Zepbound (Tirzepatide) | GLP-1 + GIP | ~20–21% | FDA-approved |
| Wegovy (Semaglutide) | GLP-1 only | ~15% | FDA-approved |
Key Takeaways
• Overall, Retatrutide activates more pathways
• Meanwhile, Zepbound outperforms Wegovy in trials
• Still, Wegovy remains effective for many patients
For a deeper breakdown, read our guide on
👉 Retatrutide vs Tirzepatide (Zepbound)
Likewise, if you are considering Semaglutide, see
👉 Wegovy (Semaglutide) for Weight Loss
Who May Be a Good Candidate for Retatrutide?
In general, Retatrutide should always be reviewed by a medical professional.
You may be a candidate if:
• Your BMI is 30 or higher
• Your BMI is 27 or higher with related conditions
• You have tried diet and exercise without success
• You want physician-guided, non-surgical care
Because everyone is different, a full medical evaluation is required.
To better understand the process, our consultation guide explains each step:
👉 Is Peptide Therapy Right for You?
Retatrutide Therapy at Azani Medical Spa in Bethlehem, PA
At Azani Medical Spa, peptide therapy is always personalized. Most importantly, it is physician-guided.
Patients may be seen in person at our Bethlehem, PA office. Additionally, telehealth is available for patients living in Pennsylvania or Florida.
Each consultation includes:
• Medical history review
• Weight and metabolic assessment
• Discussion of peptide options
• Personalized planning
• Ongoing monitoring
As a result, every plan supports long-term success.
Frequently Asked Questions
What is Retatrutide and how does it work?
In short, Retatrutide activates GLP-1, GIP, and glucagon receptors. Together, these influence appetite and metabolism.
How effective is Retatrutide for weight loss?
Based on studies, average weight loss ranges from about 24% to 29%.
Is Retatrutide FDA-approved?
No. Retatrutide is still investigational.
How does it compare with Zepbound and Wegovy?
Simply put, Retatrutide activates three pathways. Zepbound activates two. Wegovy activates one.
Are there any side effects?
Like similar therapies, mild gastrointestinal symptoms may occur. Ongoing studies continue to evaluate safety.
Schedule a Peptide Consultation
If you are ready to explore your options, our team is here to help.
Consultations are available:
✔ In person in Bethlehem, PA
✔ Via telehealth in Pennsylvania and Florida
📞 Call/Text: 610-625-3000
📅 Book Online: https://azanimedicalspa.com/request-an-appointment/
Medical Disclaimer
This content is for educational purposes only. It does not replace medical advice. Retatrutide is investigational and not FDA-approved for general use.